Daigo Kagemitsu, who works for a samurai general in Japan's Warring States period, promises to offer body parts of his unborn baby to 48 devils in exchange for complete domination of the country. Knowing the child to be deficient, Kagemitsu orders the newborn thrown into the river. The baby survives. Callling himself Hyakkimaru, he searches the world for the 48 demons.

Each time he eliminates one, he retrieves one of his missing parts. Hyakkimaru meets a boy thief named Dororo, and together they travel the countryside, confronting monsters and ghosts time and again. In this third and final volume, Hyakkimaru's saga comes to close.

Story and art by Osamu Tezuka.